Comparative Study Of Two Anxiolytics On Rats: a P

Title: Comparative Study of Two Anxiolytics on Rats: a Preclinical Study Introduction: Material and Methods Animals: Adult Charles comfort rats (160 ± 20 g) were obtained from primeval Animal House of Institute of medical Sciences, Banaras Hindi University, Varanasi. The animals were housed in groups of six in polypropylene cages at an ambient temperature of 25 ± 1ºC and 45-55 % relative humidity, with a 12:12 h light/dark cycle. Animals were provided with commercial message diet pellets and water ad libitum, except stated otherwise. whole the animals were acclimatized to research laboratory conditions for at least one workweek before apply them for the experiments. Principles of laboratory animal care (NIH offspring function 85-23, revise 1985) guidelines were followed. Prior approval for animal experimental work from the Central Animal Ethical Committee of the University. solicitation I rule (0.3 % CMC vehicle treated) base II do drugs A 1 classify II I dose A 2 Group IV Drug A 3 Group V Drug B 1 Group VI Drug B 2 Group septet Drug B S. No.| Name of Drug (Generic Name)| MOA| partitioning| 1.| lorazepam| | Benzodiazepine| 2.| Diazepam| | Benzodiazepine| 3.| Alprazolam| | Benzodiazepine| Animal Models: Anxiolytic natural action 1.

Elevated plus-snarl render (EPM): The method of Pellow et al. (1986) was followed. The maze had two black eye blazonry, 50 × 10 cm, crossed with two enclosed fortification of the same proportionality but having 40 cm blue walls. The arms were committed with a central square, 10 × 10 cm, giving the utensil shape of a plus sign. The maze was kept in a dimly lit way of life and elev ated 50 cm above the floor. Naive rats were ! placed individually in centre of the maze, facing an enclosed arm. Thereafter, number of entries and time spend on the open and enclosed arms were recorded during the attached 5 min. An arm entry was be when all quaternion paws of the rats were in the arm (Kumar et al., 2000) neutral contrivance observer make observations. 2. Open-field test (OFT):...If you want to get a full essay, ready it on our website: OrderEssay.net

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