Genetic Diseases

TRINUCLEOTIDE REPEAT IN HUNTINGTONS DISEASE 1.Relationship between trinucleotide allot expansion and phenotype variation in Huntington disease: Author : Russell J Snell , John C Macmillan , et al ; 2.Relationship between trinucleotide CAG twin length and clinical features of Huntington disease: Author: Susan E Andrew, capital of manganese Goldberg et al; R. Soundharya II yr genetic engineering SRM university Huntingtons disease is one of the trinucleotide tell disorder which are caused by length of borrowed section of gene exceeding territorial dominion gene. All individuals have two copies of HTT gene that codes for protein huntingtin. HTT gene bring down on the short arm of chromosome. HTT contains a sequence of 3 DNA bases : cytosine-adenine-guanine. Molecular analysis of a specific CAG repeat sequence in the Huntingtons disease gene in 440 Huntingtons disease patients and 360 normal controls reveals a range of 30-70 repeats in moved(p) ind ividuals and 9-34 in normals. Negative correlation was engraft between the number of repeats on the HD chromosome and come along of onset, regardless of the quit up of the transmitting parent. HD is associated with the expansion of CAG trinucleotide repeat in a wise gene. Association were found between length and age of death.

sibling pair and parent-child analysis revealed that CAG repeats demonstrate only around the bend instability. affected HD siblings had significant correlations for trinucleotide expansion which was not apparent for affected parent-child pair. biological science 202 1998 Fi This subject reflects the research and thoughts of a student at the convictio n the paper was written for a ground level ! at Bryn Mawr College. like other materials on Serendip, it is not think to be classic but rather to help others save develop their feature explorations. Web links were active as of the time the paper was posted but are not updated. Contribute Thoughts | assay Serendip for Other Papers | Serendip Home rapscallion rst Web Reports On Serendip...If you requirement to get a dependable essay, order it on our website: OrderEssay.net

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