Platelet Structure And Function

Platelet Structure and Function Platelets atomic number 18 disklike anuclear cells that part from megakaryocytes in the bone marrow, which shed their cytoplasm into blood platelet size of it fragments afterward following a pattern of differentiation and maturation. The primary(prenominal) hormone that controls megakorocyte development is thrombopoietin. The life span of a thrombocyte in the circulation is 7-10 days. Circulating platelets in a resting state are discoid in shape and approximately 0.3-0.5µm in size. The expression platelet count in a vigorous individual is 140-400x109/l. Platelets have an important role in business coagulation. When a watercraft is injured platelets immediately form a adulteress at the site of injury; this is called primary haemostasis. inessential hemostasis occurs simultaneously: Structure of blood platelets Platelets have a exceedingly specialised body structure: Figure 1 Shows the generalised structure of a platel et and organisation of the features to be discussed [pic] Platelet membrane The platelet membrane is vital to platelet function for 2 reasons: 1. It contains a number of glycoprotein receptors through which platelets react with aggregating agents, inhibitors, coagulation instruments and consequently the vessel wall and each other. some(a) of the important glycoproteins include GP1a and GP1b.

GP1a binds to collagen and GP1b binds to von Willebrands factor 2. It too contains phospholipids, which act as a rally for interaction with ad hoc components of coagulation biochemistry, such as factor II and factor X The surface connected open canalicular sytem (SCOCS) is a net income of fall throughout the inter! ior of the platelet formed from the invaginations of the membrane. These channels change magnitude the surface area of platelet exposed to plasma. This fork ups a road for molecules to reach deep within the platelet cytoplasm. They withal provide a route for extrusion of substances out of the platelet at one time it has been activated. The dense tubular system (DTS) is a...If you want to get down in the mouth a full essay, order it on our website: OrderEssay.net

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